NDOH and WHO Guidelines

Guideline for Vertical Transmission Prevention of Communicable Infections

National Department of Health

  • 13 Sep 2023

The programme that was formally known as Prevention of Mother-to-Child Transmission of Transmissible Infections, is from now onwards called the Vertical Transmission Prevention (VTP) programme. This guideline will be a component of the Maternity Care guidelines and the National Consolidated ART guidelines.

2023 ART Clinical Guidelines

National Department of Health

  • 06 Jun 2023

Clinical Guidelines for the Management of HIV in Adults, Pregnancy and Breastfeeding, Adolescents, Children, Infants and Neonates (June 2023, Version 3)

National Guidelines on the Treatment of Tuberculosis Infection

National Department of Health

  • 08 Mar 2023

The purpose is to guide implementation, the management of patients started on TPT and the monitoring and evaluation requirements. It is intended for clinicians, pharmacists and healthcare managers in the public and private sector.

Adherence Guidelines


  • 20 Feb 2023

Standard Operating Procedures - Minimum package of interventions to support linkage to care, adherence and retention in care

TB Screening and Testing Standard Operating Procedure

National Department of Health

  • 30 Jun 2022

The purpose of this document is to outline the process and procedure for quality TB screening and early identification of patients who require TB testing to minimize avoidable delays in diagnosis and treatment thus reducing TB transmission.

National Guidelines for the Management of Viral Hepatitis

National Department of Health

  • 28 Jul 2020

These guidelines were developed with the purpose to: • inform healthcare workers in the public and private sectors about the disease, its epidemiology in South Africa and current methods of diagnosis and therapy • strengthen the healthcare response to viral hepatitis • empower communicable diseases workers and stakeholders to make informed decisions regarding appropriate and cost effective interventions

2019 ART Clinical Guidelines for the Management of HIV in Adults, Pregnancy, Adolescents, Children, Infants and Neonates (March 2020 update)

National Department of Health

  • 08 May 2020

• The CD4 count threshold for TPT eligibility in pregnancy has been amended from 100 cells/µL to 350 cells/µL. This is aligned with EML and PMTCT Guideline (changes to page 7). • All clients with a positive CrAg test should be referred for a lumbar puncture. This is aligned with EML (changes to pages 4 and 6). • Removal of resistance testing for adults and adolescents failing a first-line DTG-based regimen. This is based on an assessment of current resources (changes to page 17).


National Department of Health

  • 17 Apr 2020


National Consolidated Guidelines for the Management of HIV in Adults, Adolescents, Children and Infants and Prevention of Mother-to-Child Transmission

National Department of Health

  • 28 Feb 2020

The 2019 Consolidated Guidelines have been revised to include a new formulation of the fixed dose combination (FDC) of tenofovir (TDF) 300 mg + lamivudine (3TC) 300 mg + dolutegravir (DTG) 50 mg (TLD) for all eligible adults, adolescents and children 10 years and older and weighing 35 kg or more. These guidelines have further simplified ART provision and harmonized PMTCT and the management of children, adolescents and adults with HIV/AIDS, TB and other common opportunistic infections.

Shortage of 3TC

National Department of Health

  • 07 Jun 2019


SAPHRA media release

Department of Health

  • 25 Jan 2019

Recommendations about the use of the HIV medicine DOLUTEGRAVIR in Pregnancy in response to the Potential Risk of Birth Defects

Clinical guidelines

National Department of Health

  • 29 Dec 2017

Listeriosis: Clinical recommendations for diagnosis and treatment

Application form for third-line antiretroviral therapy - updated

National Department of Health

  • 13 Oct 2017

Please find attached the application form that is required to be completed for access to Third Line Antiretroviral Therapy. Please complete the form using the following steps: • Download: Please download the PDF document. • Open: Open the PDF document using Adobe Reader. Ensure you have the latest version of the form may not work properly. • Fill: This is an editable PDF, and the minimum required fields will be highlighted. Please click on each field and enter the required patient information. Please do not print out the document to complete by hand. • Save: Once you have completed the document please save it to your computer by clicking the icon on the top left of the screen. Save it using the patient name and surname as a unique identifier. • Submit: Close Adobe and attach the completed and renamed application form to an email and submit it to the following email address: TLART@health.gov.za

DoH PrEP guidelines for sex workers

  • 09 Jun 2016

The 2016 "Guidelines for Expanding Combination Prevention and Treatment Options for Sex Workers: Oral Pre-Exposure Prophylaxis (PrEP) and Test and Treat (T&T)" have been released by the SA National Department of Health.

FDC ARV Circular

  • 25 May 2015

There are four fixed-dose ARV combinations available. Here are the NDoH guidelines for their use in first and second-line ART regimens.

NDOH circular: Implanon in EFV-containing regimens

  • 05 Nov 2014

NDOH circular on changes in the prescription of progestin subdermal implants (implanon) in women taking enzyme-inducing drugs such as efavirenz, rifampicin and certain epilepsy medicines.


  • 01 Jul 2014

Implementing all these strategies in combination will not only reduce the burden of disease in children but help us attain the goal of zero TB deaths in children. Partnerships with communities and more research into new diagnostic tests, better vaccines and child friendly medicine formulations will provide immense opportunities for attaining this goal.

NDoH Circular: Fixed Dose Combination February 2014

  • 05 Feb 2014

Circular issued by the National Department of Health stating that ALL eligible patient groups should be offered to switch to the fixed-dose combination of Tenofovir(TDF) + Emtricitabine (FTC)+ Efavirenz (EFV).

NDOH Third Line Protocol

  • 06 Sep 2013

NDOH protocol for accessing third-line antiretroviral therapy in the public sector


  • 21 Mar 2013

This document contains the short combined guidelines for antiretroviral treatment for South Africa in 2013. This document was published on 14 March 2013 by the National Department of Health. This includes standardised national guidelines for adults and adolescents, children, HIV-positive pregnant women as well as HIV-positive newborn infants.

Fixed Dose Combination Treatment Guidelines Training Slides

  • 20 Mar 2013

These presentation slides, put together by the South African National Department of Health, should aid in training staff for the correct implementation of the 2013 standardised guidelines for Fixed Dose Combination (FDC) antiretroviral therapy regimens.

Guidelines on long-acting injectable cabotegravir for HIV prevention

World Health Organization

  • 28 Jul 2022

WHO recommends that long-acting injectable cabotegravir (CAB-LA) may be offered as an additional HIV prevention option for people at substantial risk of HIV infection. CAB-LA is an injectable form of pre-exposure prophylaxis (PrEP) that has been shown to be highly effective at reducing the risk of HIV acquisition.

Global tuberculosis report 2021

World Health Organization

  • 14 Oct 2021

Each year, the WHO Global TB Report provides a comprehensive and up-to-date assessment of the TB epidemic, and of progress in prevention, diagnosis and treatment of the disease, at global, regional and country levels. This is done in the context of global TB commitments, strategies and targets.

Global tuberculosis report 2020

  • 15 Oct 2020

The 2020 WHO global TB report showcases the progress made towards ending the TB epidemic, and puts in stark perspective the current and potential impact of the COVID-19 pandemic, in eroding the hard-won gains of recent years.

Global tuberculosis report 2019


  • 18 Oct 2019

WHO has published a global TB report every year since 1997. The main aim of the report is to provide a comprehensive and up-to-date assessment of the TB epidemic, and of progress in prevention, diagnosis and treatment of the disease, at global, regional and country levels.

Guideline: counselling of women to improve breastfeeding practices

  • 31 Dec 2018

This guideline examines the evidence and makes recommendations and remarks on the implementation of some of the details of breastfeeding counselling, such as frequency, timing, mode and provider of breastfeeding counselling, to improve breastfeeding practices. The objective of this guideline is to provide global, evidence-informed recommendations on breastfeeding counselling, as a public health intervention, to improve breastfeeding practices among pregnant women and mothers who intend to breastfeed, or are currently breastfeeding, and their infants and children.

Latent TB Infection : Updated and consolidated guidelines for programmatic management

  • 15 Feb 2018

These new guidelines supersede previous WHO policy documents on the management of LTBI in people living with HIV, household contacts of people with active TB, other groups at risk of developing TB, and for LTBI testing. The consolidated guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management, adapted to the national and local epidemiology of TB, the availability of resources, the health infrastructure and other national and local determinants. The guidelines are to be used primarily in national TB and HIV control programmes, or their equivalents in ministries of health, and for other policy-makers working on TB and HIV and infectious diseases. They are also appropriate for officials in other line ministries with work in the areas of health.

Fast tracking combination prevention

  • 16 Nov 2015

This report from UNAIDS and the WHO discusses the six elements of HIV prevention efforts that are crucial to achieve the target of reducing HIV incidence to 500 000 or fewer by 2020. commitment, focus, synergies, innovation, coverage and accountability

Guidelines for the Delivery of Antiretroviral Therapy to Migrants and Crisis-Affected Persons in Sub-Saharan Africa

  • 17 Apr 2015

Update to 2007 guidance to include all types of migrants and crisis-affected populations, including those forcibly displaced. This update stresses that migration and forced displacement must NO T be used as an excuse to deny treatment. Clear recommendations are provided for states, clinicians and programme managers, civil society, donors and United Nations (UN ) agencies.

Updated WHO PEP Guidelines

  • 05 Feb 2015

The updated WHO Guidelines on post-exposure prophylaxis for HIV for adults, adolescents and children were launched in January 2015